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Agents Are Going Async

Async subagents let an agent stay responsive while background workers run long tasks. How the orchestrator, notifications and approvals work in Deep Agents.

VirtualTrialHarness: Coordinating Agentic Operationalization of Virtual Trial Protocols Across Complex Clinical Schemas

arXiv:2611.05551v1 Announce Type: new Abstract: Virtual trials use routinely collected clinical data to evaluate treatment strategies, but translating a study protocol into an executable analysis requires determining how clinical concepts and study requirements should be represented in the available data and applied consistently across the workflow. These decisions depend on local data representations and operational conventions and can involve source selection, patient and encounter identity, linkage, and temporal interpretation. Here we introduce VirtualTrialHarness (VTHarness), an agent framework that coordinates virtual-trial operationalization by selecting reusable procedural skills for each workflow stage and uses explicit contracts to maintain consistent study decisions across stages. We also introduce VTBenchmark for evaluating source selection and cohort construction. Across three complex synthetic environments, VTHarness successfully produced all required cohort outputs matching the references in 95.1% of workflows after requirement clarification, compared with 60.4% using retrieval from the same procedural corpus. Procedural skills improved source recovery across three language models and increased source overlap with analyst code in 13 Mayo Clinic cases. Site-specific adaptation enabled reference-matched cohort execution across eight MIMIC-IV tasks. Within the Mayo Clinic Virtual Trials Program, the framework supported investigator review of cohort construction and endpoint analysis. These findings support coordinating procedural guidance with workflow decisions to improve virtual-trial implementation across complex clinical schemas.

v1.19.0 - Trace Your Workflows, Layer by Layer

Dify 1.19.0 enhances observability with nested workflow tracing, allowing users to follow execution steps inside Workflow Tools, inspect LLM calls, and maintain context across nested invocations. The release also enables portable app packages via App packages, improves Agent file uploads and previews, introduces Skill Hub automation through CLI commands, and upgrades the bundled plugin daemon to version 0.6.14-local. Key changes include support for format v2 app packages, enhanced security, improved editing workflows, and updated environment variables and API endpoints.

n8n@3.0.0

# [3.0.0](https://github.com/n8n-io/n8n/compare/n8n@2.45.0...n8n@3.0.0) (2026-10-27) ### Bug Fixes * Add file-type tooltip to artifact download button ([#41490](https://github.com/n8n-io/n8n/issues/41490)) ([4a74f02](https://github.com/n8n-io/n8n/commit/4a74f027e612f31098b354dd3a77b2c2ab98281c)) * **ai-builder:** Check execution:read in Assistant execution reads ([#41863](https://github.com/n8n-io/n8n/issues/41863)) ([a967486](https://github.com/n8n-io/n8n/commit/a9674866d075e989a5ce896432262c9a7dc8b0c7)) * **ai-builder:** Send Assistant model calls through the configured AI transport ([#41948](https://github.com/n8n-io/n8n/issues/41948)) ([9b63561](https://github.com/n8n-io/n8n/commit/9b63561cbb48f06d216f27be3b77722d97e4e74a)) * Allow custom OAuth2 scopes ([#41249](https://github.com/n8n-

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n8n@2.46.0

# [2.46.0](https://github.com/n8n-io/n8n/compare/n8n@2.45.0...n8n@2.46.0) (2026-10-27) ### Bug Fixes * Add file-type tooltip to artifact download button ([#41490](https://github.com/n8n-io/n8n/issues/41490)) ([4a74f02](https://github.com/n8n-io/n8n/commit/4a74f027e612f31098b354dd3a77b2c2ab98281c)) * **ai-builder:** Check execution:read in Assistant execution reads ([#41863](https://github.com/n8n-io/n8n/issues/41863)) ([a967486](https://github.com/n8n-io/n8n/commit/a9674866d075e989a5ce896432262c9a7dc8b0c7)) * **ai-builder:** Send Assistant model calls through the configured AI transport ([#41948](https://github.com/n8n-io/n8n/issues/41948)) ([9b63561](https://github.com/n8n-io/n8n/commit/9b63561cbb48f06d216f27be3b77722d97e4e74a)) * Allow custom OAuth2 scopes ([#41249](https://github.com/n8

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v0.43.0

## What's Changed * model_prefetch: syncrhonize all graph cleanups by @rattus128 in https://github.com/Comfy-Org/ComfyUI/pull/17178 * Add rope scaling support to MOSS-image by @kijai in https://github.com/Comfy-Org/ComfyUI/pull/17172 * [Partner Nodes] Renew partner-node sign-in tokens in API nodes by @dante01yoon in https://github.com/Comfy-Org/ComfyUI/pull/16943 * [Partner Nodes] feat(HeyGen): add HeyGen Voice instant clone and text-to-speech by @bigcat88 in https://github.com/Comfy-Org/ComfyUI/pull/17043 * [Partner Nodes] feat(ClarityAI): add Crystal Video Upscaler node by @bigcat88 in https://github.com/Comfy-Org/ComfyUI/pull/17192 * [Partner Nodes] feat(BFL): add 2K/4K resolutions to FLUX 3 Video nodes by @bigcat88 in https://github.com/Comfy-Org/ComfyUI/pull/17200 * Support MOSS-image

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AWS releases a technical preview: Amazon Quick and Bedrock AgentCore enable the construction of governable, conversational supply chain intelligence systems.

AWS has launched a modular agent architecture based on the Model Context Protocol (MCP), leveraging AgentCore to standardize enterprise‑level tool interfaces. Amazon Quick provides a natural‑language interaction interface for business users, enabling real‑time, approval‑driven supply chain decision support across ERP, procurement, monitoring, and other systems. This solution is currently in technical preview and is not guaranteed to be production‑ready or available for customer deployment.

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