Agents Are Going Async
Async subagents let an agent stay responsive while background workers run long tasks. How the orchestrator, notifications and approvals work in Deep Agents.
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VirtualTrialHarness: Coordinating Agentic Operationalization of Virtual Trial Protocols Across Complex Clinical Schemas
arXiv:2611.05551v1 Announce Type: new Abstract: Virtual trials use routinely collected clinical data to evaluate treatment strategies, but translating a study protocol into an executable analysis requires determining how clinical concepts and study requirements should be represented in the available data and applied consistently across the workflow. These decisions depend on local data representations and operational conventions and can involve source selection, patient and encounter identity, linkage, and temporal interpretation. Here we introduce VirtualTrialHarness (VTHarness), an agent framework that coordinates virtual-trial operationalization by selecting reusable procedural skills for each workflow stage and uses explicit contracts to maintain consistent study decisions across stages. We also introduce VTBenchmark for evaluating source selection and cohort construction. Across three complex synthetic environments, VTHarness successfully produced all required cohort outputs matching the references in 95.1% of workflows after requirement clarification, compared with 60.4% using retrieval from the same procedural corpus. Procedural skills improved source recovery across three language models and increased source overlap with analyst code in 13 Mayo Clinic cases. Site-specific adaptation enabled reference-matched cohort execution across eight MIMIC-IV tasks. Within the Mayo Clinic Virtual Trials Program, the framework supported investigator review of cohort construction and endpoint analysis. These findings support coordinating procedural guidance with workflow decisions to improve virtual-trial implementation across complex clinical schemas.
Rethinking Next-Visit Diagnosis Prediction Beyond Aggregate Metrics: Retrieval--Memory Multi-Agent Adjudication
arXiv:2611.03826v1 Announce Type: new Abstract: Next-visit diagnosis prediction forecasts the diagnoses documented at a patient's next encounter, turning retrospective electronic health records into prospective clinical prediction. However, conventional aggregate evaluation obscures its multifaceted nature: distributionally, models must handle variable-size diagnosis sets and long-tailed labels; temporally, they must distinguish persistent, newly recorded, and recurrent diagnoses; and both vary with observed history depth. We introduce an evaluation framework along these dimensions and apply it to rule-based heuristics, LLM-based prompting, retrieval, memory, and multi-agent approaches. This reveals that repeating the last visit outperforms most LLM-based approaches overall despite predicting no new or recurrent diagnoses, and that retrieval and memory exhibit distinct profiles whose relative strengths vary across temporal transitions and backbones. Motivated by this, we propose LONGINUS, a retrieval-memory multi-agent adjudication framework combining evidence retrieved from patient records with structured memory of the patient trajectory. Using cross-view agreement as a reliability heuristic, it preserves shared predictions and adjudicates disagreements without revealing their source. Across MIMIC-III and MIMIC-IV with four LLM backbones, LONGINUS achieves the best transition-specific performance among LLM-based methods in nearly all settings while remaining competitive with them on aggregate metrics.
v1.19.0 - Trace Your Workflows, Layer by Layer
Dify 1.19.0 enhances observability with nested workflow tracing, allowing users to follow execution steps inside Workflow Tools, inspect LLM calls, and maintain context across nested invocations. The release also enables portable app packages via App packages, improves Agent file uploads and previews, introduces Skill Hub automation through CLI commands, and upgrades the bundled plugin daemon to version 0.6.14-local. Key changes include support for format v2 app packages, enhanced security, improved editing workflows, and updated environment variables and API endpoints.
How to Build Proactive, Always-On Agents with the Schedules SDK in Managed Deep Agents
Most proactive agents run on a simple cron. Learn what scheduled runs unlock, from memory to smart triage, and how to add them to Managed Deep Agents.
How to build evidence-grounded agent memory with OpenWiki and Graphs
LangChain used OpenWiki, its open-source wiki compiler, and an evidence graph to build a persistent memory layer that preserves knowledge for agents to reuse across tasks. Learn how.
How LangChain grew self-serve analytics questions 40x by giving its AI agent layered context
LangChain gave its Hex agent layered context, turning self-serve analytics questions from occasional to routine.
How We Built Our Design Agent
How LangChain built Content Studio, an open-source design agent in Slack that makes on-brand videos, graphics and decks, and the harness that powers it.
Distill, Debate, Discover: Grounding Multi-Agent Research Ideation in Graph-Distilled Insights
arXiv:2610.33366v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly used to support research idea generation and scientific discovery. Multi-agent debate offers a collaborative approach to this task by bringing together diverse perspectives to develop research ideas. However, a key challenge is how to equip agents with distinct and meaningful expertise to guide their contributions. Inspired by how researchers draw on accumulated research experience during collaboration, we introduce InsightAgents, a framework that constructs literature-grounded agent expertise by distilling insights from graphs of related papers. Guided by insights that trace evolving research approaches, reveal underlying assumptions, and identify unresolved challenges, within a line of research,
Context Engineering (Agent Memory) for AI Agents Starts with Retrieval
Agents waste time and context on clumsy searches, oversized results and stale data. Learn the retrieval techniques LangChain's Deep Agents harness uses to get the right context in.
Context Engineering with Deep Agents: How To Remember Without Keeping Everything In Context
Long-running agents degrade as context piles up. Learn how offloading, summarization, skills, subagents, and memory keep your agent's context window focused.
DraMaze: A Multi-Agent Pipeline with Future-Aware Memory for Diverse Microdrama Script Generation
arXiv:2610.32002v1 Announce Type: new Abstract: The rapid growth of microdramas has increased demand for high-quality script production. Long-form microdrama script generation with LLMs requires both diverse plot progression and long-range narrative coherence. Our observations reveal that candidate continuations increasingly concentrate on fewer narrative mechanisms as generation progresses, while conventional retrieval may reinforce trope reuse and overlook historical information essential to future plots. To address these challenges, we propose DraMaze, a multi-agent pipeline that explores diverse causal paths through trope memory-guided evolutionary tree search and mutation. It further constructs a Backward Narrative Dependency Tree to organize, retain, and retrieve historical memories
Permission to Retry: A Study of Authorization and Recovery in AI Agent Workflows
arXiv:2610.31916v1 Announce Type: new Abstract: A durable agent can resume a consequential action while its authority changes and the action's external outcome remains uncertain. We study execution-time reliability of tool-using AI agents, isolating recovery decisions from language-model behavior. Checkpoint state, permission to dispatch, evidence of an external effect and permission to reconcile are distinct obligations. We present a finite conformance study that checks these obligations through histories scored against a provider effect ledger hidden from the recovering application. A prospectively frozen campaign executes 336 histories on native LangGraph and Temporal hosts, crossing 14 schedules, three provider contracts and four matched application policies. All 168 paired host cells
