MODEL PROFILE

ESMC-300M

biohub · ESMC-300M

ESMC is a state-of-the-art protein language model that has learned the rules of protein biology from training on billions of protein sequences. ESMC provides representations of proteins enabling novel AI applications from therapeutic protein engineering to unlocking basic insights into protein biology across life. The ESMC 6B model has 6 billion parameters, with 80 layers and 2.37e23 training flops. We additionally release overtrained 300M and 600M parameter variants of ESMC for local inference and finetuning. The ESMFold2 structure prediction models are trained on top of a frozen ESMC 6B language model. ESMFold2 is a state-of-the-art model for protein structure prediction and design that defines a new frontier for speed and accuracy.

Fill-masklicense:mitlicense:other
Context windowNot disclosed
Input → OutputText → Text
Model weightsNot verified
Profile updated2026/10/29 06:14:00
OVERVIEW

Model overview

ESMC is a state-of-the-art protein language model that has learned the rules of protein biology from training on billions of protein sequences. ESMC provides representations of proteins enabling novel AI applications from therapeutic protein engineering to unlocking basic insights into protein biology across life. The ESMC 6B model has 6 billion parameters, with 80 layers and 2.37e23 training flops. We additionally release overtrained 300M and 600M parameter variants of ESMC for local inference and finetuning. The ESMFold2 structure prediction models are trained on top of a frozen ESMC 6B language model. ESMFold2 is a state-of-the-art model for protein structure prediction and design that defines a new frontier for speed and accuracy.

Key features

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Limitations & considerations

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PRICING & COST

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INDEPENDENT BENCHMARKS

Public benchmarks & run configuration

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Frequently asked questions

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Sources & traceability

许可证:mit。模型介绍与第三方评测均以原来源的具体版本和方法为准。